Comparing dissolution, solubility and trans-membrane flux of nanoparticle formulation of griseofulvin with micronized and un-processed drug

Recently developed Zero Intercept Method1 (ZIM) enabling, for example, in situ concentration monitoring Figure 9 shows example of the dissolution and appearance profiles for various forms of GSF. of free API being released from nanoparticles was applied to determine solubility and dissolution of gresiofulvin formulated as nanosuspension. The effect of formulation was also studied through miniaturized dissolution-permeability setup (μFLUX) to determine if nanosuspension formulation improves flux of the griseofulvin through artificial membrane.

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