Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

It has been shown1,2, that disk intrinsic dissolution rate (IDR) can be determined from powder dissolution experiments for BCS Class III and IV (low soluble) compounds and that particle size information could be extracted from powder dissolution experiments. This research investigates if such studies could be conducted in the 96-well microtitre plate format. A newly developed device was applied to asses the feasibility of performing in situ (real time) UV concentration monitoring experiments in volumes as low as 100 -200 μL.

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