Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug–Drug Interaction from pH Modifying Agents

It has been shown that miniaturized two stage in vitro dissolution test1 can be used to understand why some low soluble weak basic drugs show reduced or highly variable absorption when coadministered with pH-modifying agents. The goal of this study was to demonstrate that an absorption chamber combined with USP 1 and 2 dissolution apparatus can be used to study similar drug-drug interactions (DDI) of the final dosage forms.

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