Effect of Simulated Mucus Environment on the Supersaturation of Carvedilol and Its Flux through Artificial Lipophilic Membranes

Itwashypothesizedandthendemonstrated1thatsmallintestinalmucuslayercouldstabilizesupersaturatedstateofotherwiseprecipitatinglowsolubilitydrugs.Itwasalsoconcluded2thatfluxmeasurementsprovidemorein-depthunderstandingofsupersaturatedsystemsthansoluteconcentrationmeasurementsalone.Thisstudyusedminiaturizeddissolution–permeationapparatus(μFLUX)tocomparefluxofcarvedilolthroughartificialmembranesfromasimplebuffersystemaswellasfrommediasimulatingthemucuslayerand/orcontainingsolubilizingexcipientslikehydroxypropyl-ß-cyclodextrin.

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