Prediction of Caco-2 pH-Dependent Permeability based on High-Quality in vitro Training Set

The aim of the study was to predict the pH-dependent permeability profiles of drugs in a Caco-2 assay, using an in combo procedure based on measured Double-Sink™ PAMPA permeability values and the calculated Abraham solvation descriptors (
, , , R, Vx).

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